≥99% PurityMelanocortin & Hormonal
PT-141
Melanocortin agonist investigated in central nervous system pathway studies.
Strength
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About this compound
Molecular Specifications
PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist that differs from Melanotan II by a single structural feature: a C-terminal free acid (-OH) rather than amide (-NH2) group. Despite this minor modification, PT-141 shows preferential activity at MC4R vs. MT-II's broader pan-MCR activity. Bremelanotide was approved by the FDA in 2019 under the brand name Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women, providing a well-characterized human pharmacological dataset for laboratory research context.
MC4R CNS Mechanism
Unlike PDE5 inhibitors that act peripherally on vascular smooth muscle, PT-141 acts centrally through MC4R activation in hypothalamic circuits that regulate sexual motivation and arousal. The paraventricular nucleus (PVN) of the hypothalamus, which has high MC4R density, is the primary CNS locus studied for melanocortin-mediated sexual behavior effects in animal models.
Research Applications
- MC4R central nervous system pharmacology studies
- Hypothalamic sexual behavior circuit research
- Comparison studies vs. Melanotan II for MCR selectivity
- Female sexual function pathway research in preclinical models
- CNS vs. peripheral mechanism distinction in sexual function research
- Melanocortin system comparative pharmacology
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. PT-141 is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is PT-141?
Research Applications
PT-141 in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
PT-141 research FAQ
What purity is PT-141 tested to?+
Every batch of PT-141 is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is PT-141 intended for human use?+
No. PT-141 is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should PT-141 be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships PT-141 domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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