≥99% PurityMelanocortin & Hormonal
Melanotan II
Melanocortin receptor agonist studied for pigmentation pathway research.
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About this compound
Molecular Specifications
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) developed at the University of Arizona. As a non-selective melanocortin receptor agonist with affinity for MC1R, MC3R, MC4R, and MC5R, MT-II has been widely used in basic research to study the melanocortin receptor system across its full expression pattern. The D-Phe substitution at position 7 dramatically increases potency and receptor residence time relative to the linear α-MSH parent peptide.
Melanocortin Receptor Biology
MC1R: Expressed in melanocytes. Regulates pigmentation — driving eumelanin (brown/black) vs. pheomelanin (yellow/red) production. Key research receptor for UV response, tanning biology, and skin cancer risk pathway research.
MC3R: Expressed in brain, gut, and immune cells. Studied for energy homeostasis, inflammation, and cardiovascular regulation research.
MC4R: Extensively expressed throughout the CNS, particularly hypothalamic nuclei. The most studied melanocortin receptor in feeding behavior, energy balance, and sexual behavior neuroendocrinology research.
MC5R: Expressed in exocrine glands. Studied for sebum production and exocrine function pathway research.
↗ Hadley ME, Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones. Peptides. PubMed: 16872718
Research Applications
- Non-selective melanocortin receptor system pharmacology studies
- Pigmentation pathway research via MC1R activation
- Energy balance and feeding behavior research (MC4R)
- Sexual behavior neuroendocrinology in animal models
- Comparison studies vs. selective MCR agonists/antagonists
- MC5R exocrine function studies
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. Melanotan II is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is Melanotan II?
Research Applications
Melanotan II in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
Melanotan II research FAQ
What purity is Melanotan II tested to?+
Every batch of Melanotan II is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is Melanotan II intended for human use?+
No. Melanotan II is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should Melanotan II be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships Melanotan II domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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