≥99% PurityGrowth Hormone Secretagogues
CJC-1295 No DAC
GHRH-analog research peptide studied for short-acting pulsatile signaling.
Strength
Package
💰 Buy more, save more — 5-pack 10% off · 10-pack 15% off
Need larger volumes? Bulk & wholesale pricing available — contact us.
Discount code
Discount codes apply to single-bottle items only and cannot be combined with multi-pack (5-/10-pack) pricing.
About this compound
Molecular Specifications
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic analog of the first 29 amino acids of GHRH incorporating four strategic amino acid substitutions that confer resistance to DPP-IV cleavage. These substitutions extend the half-life from native GHRH's <7 minutes to approximately 30 minutes — long enough to reliably stimulate GH pulses in research models while maintaining a pulsatile pharmacokinetic profile.
Structural Modifications
The four substitutions from native GHRH 1-29 are: Ala2→D-Ala (DPP-IV resistance), Gln8→Ala (improved stability), Ala15→Ala (optimized binding), and Leu27→Arg (enhanced activity). Together these modifications preserve GHRH-R binding affinity while dramatically improving in-vivo stability.
Pulsatile vs. Sustained GH Release Research
CJC-1295 without DAC is the tool of choice for studying pulsatile GH dynamics — the physiological pattern of GH secretion characterized by discrete peaks separated by troughs. Its 30-minute half-life produces GH peaks that clear within hours, mimicking endogenous pulsatility. This contrasts with CJC-1295 with DAC, whose 7–10 day half-life produces sustained, continuous GH elevation — a fundamentally different research model.
Research Applications
- GHRH receptor activation and pulsatile GH secretion studies
- GH pulsatility research in animal models
- Comparison vs. CJC-1295 with DAC for pulsatile vs. sustained GH models
- Combination studies with ipamorelin (dual-pathway GH release)
- IGF-1 axis pathway research downstream of GH stimulation
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. CJC-1295 No DAC is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is CJC-1295 No DAC?
Research Applications
CJC-1295 No DAC in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
CJC-1295 No DAC research FAQ
What purity is CJC-1295 No DAC tested to?+
Every batch of CJC-1295 No DAC is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is CJC-1295 No DAC intended for human use?+
No. CJC-1295 No DAC is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should CJC-1295 No DAC be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships CJC-1295 No DAC domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
Continue researching
Related compounds
Customer Reviews
What researchers say about CJC-1295 No DAC
—
Be the first to review
Loading reviews…
Related Compounds
