≥99% PurityGrowth Hormone Secretagogues
Ipamorelin
Selective growth-hormone secretagogue studied for pulsatile GH release.
Strength
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About this compound
Molecular Specifications
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue developed by Novo Nordisk. It is distinguished from earlier GHS compounds (GHRP-2, GHRP-6, hexarelin) by its high selectivity for the growth hormone secretagogue receptor (GHSR-1a) with minimal stimulation of cortisol, ACTH, and prolactin release — a selectivity profile that makes it a cleaner and more interpretable GH research tool.
GHSR-1a Mechanism
GHSR-1a (the ghrelin receptor) is a Gq/11-coupled GPCR expressed primarily in pituitary somatotrophs, hypothalamic neurons, and multiple peripheral tissues. Ipamorelin mimics endogenous ghrelin at this receptor, stimulating acute pulsatile GH release from pituitary somatotrophs.
Selectivity comparison: GHRP-6 at the same GH-stimulating dose produces significant cortisol increases and prolactin elevation in animal models — side effects absent with ipamorelin at equivalent doses. This selectivity makes ipamorelin the preferred GHSR-1a agonist for isolating GH-specific pathway research.
↗ Raun K et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. PubMed: 9849822
Research Applications
- GHSR-1a selective agonism and receptor pharmacology studies
- Pulsatile GH secretion modeling in preclinical settings
- Growth hormone axis research — pituitary somatotroph function
- Selectivity comparison studies vs. GHRP-2, GHRP-6
- IGF-1 axis pathway research downstream of GH release
- Combination studies with CJC-1295 for dual-pathway GH release models
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. Ipamorelin is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is Ipamorelin?
Research Applications
Ipamorelin in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
Ipamorelin research FAQ
What purity is Ipamorelin tested to?+
Every batch of Ipamorelin is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is Ipamorelin intended for human use?+
No. Ipamorelin is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should Ipamorelin be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships Ipamorelin domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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