≥99% PurityGrowth Hormone Secretagogues
IGF-1 LR3
Long-acting IGF-1 analog used in cellular growth and signaling studies.
Strength
Package
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Discount code
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About this compound
Molecular Specifications
IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic analog of IGF-1 engineered with two structural modifications: an N-terminal 13-amino acid extension beginning with Met-Arg, and a glutamic acid to arginine substitution at position 3. These changes dramatically reduce binding affinity to all six insulin-like growth factor binding proteins (IGFBP-1 through IGFBP-6) — the serum proteins that normally sequester ~99% of circulating IGF-1 — resulting in a compound with far more free receptor-accessible peptide per dose and a dramatically extended half-life.
IGF-1R Signaling Pathways
IGF-1 LR3 binds IGF-1R — a receptor tyrosine kinase with structural homology to the insulin receptor. Binding activates two major downstream pathways:
PI3K/Akt pathway: The primary anabolic and survival signaling cascade. Akt phosphorylation activates mTOR, stimulating protein synthesis via S6K1 and 4E-BP1, and inhibiting FOXO transcription factors that drive atrophy gene expression.
MAPK/ERK pathway: The proliferative signaling cascade. ERK1/2 activation promotes cell cycle progression and cell proliferation — relevant to satellite cell biology research.
Research Applications
- IGF-1R receptor binding kinetics and signaling studies
- PI3K/Akt/mTOR anabolic signaling pathway research
- Satellite cell proliferation and muscle regeneration biology
- GLUT4 translocation and glucose uptake studies
- Comparison studies with native IGF-1 for IGFBP binding dynamics
- Cancer biology — IGF-1R overexpression model research
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. IGF-1 LR3 is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is IGF-1 LR3?
Research Applications
IGF-1 LR3 in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
IGF-1 LR3 research FAQ
What purity is IGF-1 LR3 tested to?+
Every batch of IGF-1 LR3 is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is IGF-1 LR3 intended for human use?+
No. IGF-1 LR3 is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should IGF-1 LR3 be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships IGF-1 LR3 domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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