≥99% PurityCognitive & Longevity
NAD+
Coenzyme studied for cellular bioenergetics and longevity pathways.
Strength
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About this compound
Molecular Specifications
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells, participating in over 500 enzymatic reactions as a hydride acceptor in redox chemistry and as a substrate for critical enzyme classes including sirtuins, PARPs, CD38, and NAMPT. NAD+ occupies a uniquely central position in cellular metabolism research — it is simultaneously an energy metabolism cofactor and a signaling molecule whose concentration regulates epigenetic, DNA repair, and longevity pathway enzymes.
NAD+ levels decline significantly with age across multiple tissues in mammalian systems, a finding documented in rodent, primate, and human studies. This age-related decline has generated intense research interest in NAD+ biology and positioned it as one of the most studied molecules in longevity and aging pathway research over the past decade.
Primary Research Pathways
Sirtuin (SIRT1–7) pathway: Sirtuins are NAD+-dependent deacylase enzymes regulating gene expression, DNA repair fidelity, mitochondrial biogenesis, and stress response. Because NAD+ is consumed as a co-substrate during sirtuin catalysis, NAD+ availability is rate-limiting for sirtuin activity.
PARP pathway: PARP1 is activated by DNA strand breaks and consumes NAD+ during DNA damage response. The NAD+-PARP interplay is studied in aging biology, cancer biology, and chemotherapy research models.
CD38 pathway: CD38 glycohydrolase is the dominant NAD+-consuming enzyme in most mammalian tissues. CD38 activity increases with age and inflammatory states and represents a primary driver of age-related NAD+ decline.
↗ Verdin E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science. PubMed: 26785483
Research Applications
- Sirtuin activation and deacylase pathway biology
- DNA repair mechanism research via PARP activation models
- Cellular energy metabolism and mitochondrial function
- Aging biology and NAD+ decline trajectory studies
- CD38 pathway and NAD+ metabolism regulation
- Redox biology (NAD+/NADH ratio measurements)
- Caloric restriction mimetic pathway research
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. NAD+ is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is NAD+?
Research Applications
NAD+ in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
NAD+ research FAQ
What purity is NAD+ tested to?+
Every batch of NAD+ is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is NAD+ intended for human use?+
No. NAD+ is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should NAD+ be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships NAD+ domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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