≥99% PurityRegenerative & Repair
ARA-290
EPO-derived peptide studied for innate repair receptor signaling.
Strength
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About this compound
Molecular Specifications
ARA-290 (Cibinetide) is a synthetic 11-amino-acid peptide (pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser) developed by Michael Brines, Anthony Cerami and colleagues. Its sequence reproduces the aqueous face of helix B of erythropoietin (EPO), capped with an N-terminal pyroglutamate. The peptide was engineered to keep EPO's tissue-protective signaling while removing its red-blood-cell-stimulating activity.
| Other names | Cibinetide, ARA 290, pHBSP (pyroglutamate helix B surface peptide) |
|---|---|
| CAS number | 1208243-50-8 |
| Molecular formula | C51H84N16O21 |
| Molecular weight | 1257.3 g/mol |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Form | Lyophilized white powder |
| Purity | ≥99% (HPLC + MS) |
Innate Repair Receptor Mechanism
ARA-290 is a selective ligand for the innate repair receptor (IRR), a heterocomplex of the EPO receptor and the β-common receptor (CD131). The IRR is distinct from the EPO receptor homodimer that drives erythropoiesis, and it is upregulated in tissue under injury or metabolic stress.
Published research has documented that IRR engagement by ARA-290 activates JAK2-linked survival signaling, suppresses pro-inflammatory cytokine release from macrophages, and reduces microglial activation in rodent neuropathic pain models. Despite a plasma half-life of roughly two minutes, downstream effects have been reported to persist well beyond the exposure window in laboratory models.
Clinical Development Context
Cibinetide has been investigated in Phase 2 clinical trials for sarcoidosis-associated small-fiber neuropathy and for neuropathic symptoms in type 2 diabetes, where corneal nerve fiber density was used as an endpoint. Published clinical data provides human-scale pharmacological context for laboratory model design.
Research Applications
- Innate repair receptor (EPOR/CD131) signaling research
- Small-fiber and peripheral nerve injury models
- Neuropathic pain and microglial activation studies
- Inflammatory cytokine and macrophage activation research
- Ischemia and tissue-protection pathway investigation
- Metabolic inflammation and islet-protection models
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. ARA-290 is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is ARA-290?
Research Applications
ARA-290 in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
ARA-290 research FAQ
What purity is ARA-290 tested to?+
Every batch of ARA-290 is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is ARA-290 intended for human use?+
No. ARA-290 is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should ARA-290 be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships ARA-290 domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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