≥99% PurityGLP-1 & Incretin
Cagrilintide
Long-acting amylin analog investigated in metabolic and satiety research.
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About this compound
Molecular Specifications
Cagrilintide is a synthetic long-acting analog of amylin (islet amyloid polypeptide, IAPP), the peptide co-secreted with insulin from pancreatic beta cells. Engineered with a C-terminal fatty acid modification for extended albumin binding, cagrilintide achieves a half-life of approximately 7 days — enabling once-weekly dosing models compared to native amylin's half-life of minutes.
Amylin receptors are heteromeric complexes of the calcitonin receptor (CTR) with receptor activity-modifying proteins (RAMP1, RAMP2, or RAMP3). These complexes are expressed prominently in the area postrema and hypothalamic arcuate nucleus — key nodes in the gut-brain satiety signaling circuit.
Research Context
Cagrilintide has been studied primarily as a complement to GLP-1 receptor agonists. The CagriSema combination (cagrilintide + GLP-1 (S)) demonstrated substantial metabolic effects in published Phase 2 data, informing current Phase 3 investigation. The mechanistic rationale is dual-pathway satiety engagement: amylin receptor (cagrilintide) + GLP-1R (GLP-1 (S)).
Preclinical research has investigated amylin pathway activation for: gastric emptying rate modulation, glucagon suppression, area postrema-mediated satiety signaling, and complementary effects with GLP-1R agonism.
↗ Lau DCW et al. (2023). Weekly cagrilintide (2.4 mg) plus GLP-1 (S) (2.4 mg) in adults. Lancet. DOI: 10.1016/S0140-6736(23)01800-X
Research Applications
- Amylin receptor (CTR/RAMP) pharmacology and binding studies
- Satiety pathway and gut-brain axis investigation
- Gastric motility pathway research
- Combination studies with GLP-1R agonists
- Comparative amylin receptor kinetics vs. native amylin and pramlintide
Storage & Handling
Store lyophilized powder at −20°C for long-term stability; short-term 2–8°C is acceptable. Reconstitute with bacteriostatic water; keep refrigerated at 2–8°C after reconstitution and use within typical research timelines.
For laboratory and research use only. Not for human or veterinary use, diagnostic, or therapeutic applications. Statements have not been evaluated by the FDA.
Research Disclaimer: The information below is provided for laboratory and research-use-only educational purposes. It is not medical advice. Cagrilintide is not intended for human or veterinary use, diagnosis, or therapy, and statements have not been evaluated by the FDA.
Compound Overview
What is Cagrilintide?
Research Applications
Cagrilintide in research models
Mechanism of Action
Receptor & pathway interactions studied
Purity & Testing
HPLC + mass-spec verification
Storage & Reconstitution
Handling lyophilized peptides
Researchers typically reconstitute with bacteriostatic water. Browse research supplies →
Frequently Asked
Cagrilintide research FAQ
What purity is Cagrilintide tested to?+
Every batch of Cagrilintide is tested by HPLC for purity (≥99% by area) and confirmed by mass spectrometry. The lot-specific Certificate of Analysis is available on this product page.
Is Cagrilintide intended for human use?+
No. Cagrilintide is supplied strictly for laboratory and research-use-only investigation. It is not intended for human or veterinary use, diagnosis, or therapy.
How should Cagrilintide be stored?+
Store the lyophilized powder at −20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within typical research timelines.
Do you ship within the United States?+
Yes. TX Research Peptides ships Cagrilintide domestically within the US with flat-rate shipping. Orders ship from the US for fast delivery to research labs.
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